CREATIONISM IS CORRECT - Part 2

Date:         Sat, 08 Apr 95 23:29:00 EDT

Subject:      Creationism Is Correct (2/2)


                         CREATIONISM IS CORRECT - Part 2

   "Science: Evolution Beetle that may explode the ideas of Darwin."


                          By Robert Matthews

                         (The Daily Telegraph)

                         (July 22, 1991; p.12)


                     "An insect that has undergone


         three mutations cannot be the product of mere chance.


      Robert Matthews asks whether it offers proof of a Creator."


   Scuttling about in the undergrowth of Florida is  a  little  beetle


which points up a controversial problem in modern biology.  Called the


Bombardier beetle,  it has a defence system that is  little  short  of


miraculous.   Indeed,   "creationists"  -  who  claim  that  God,  not


evolution,  is responsible for all living creatures - see this  insect


as proof of their arguments.  The Bombardier carries around inside its


body an explosive mixture of chemicals.  Fortunately for  the  beetle,


they  are  normally  prevented from going off by a chemical inhibitor.


But when the Bombardier is threatened,  it injects another chemical  -


an  anti-inhibitor - into the mix.  This triggers the manufacture of a


boiling-hot vapour of noxious gunk which the  Bombardier  sprays  over


its  attackers  from  a  rotatable pipe built into its underside.  The


scientific problem the Bombardier illustrates is that of creating such


a creature from random mutations of its genes,  with natural selection


picking  out  the most useful mutations.  Suppose,  for example,  that


millions of years ago one Bombardier underwent a mutation that enabled


it to make the explosive chemicals.  Unless  it  was  very  lucky,  it


would never live to try out its new-found capability.  It would simply


explode.  To survive,  it needs  a  second  mutation  -  to  make  the


inhibitor  chemical.  But  a  beetle  with  both these mutations is no


better off than one without the  explosive  chemicals.  To  enjoy  any


benefit,  the  beetle  needs  a third mutation,  this time to make the


anti-inhibitor. We are back to the exploding beetle problem. In short,


the Bombardier appears to demand that all the random mutations  needed


for its amazing abilities occur at the same time. Yet given the rarity


of  a  single  useful  mutation occurring,  the idea of many occurring


simultaneously stretches credulity to the limit.  Creationists have  a


ready answer - God. This eliminates the problem of simultaneous random


mutations;  they are simply not involved.  Scientists counter that the


answer may be that the Bombardier got some benefit from having just  a


little  of  the  explosive  chemical,  and this led it to survive long


enough to undergo other mutations.  EVEN so,  the  beetle  graphically


illustrates  a  nagging  problem  in biology:  are mutations more than


simply random?  In particular,  are living creatures able to influence


mutations themselves,  to ensure maximum benefit?  In the latest issue


of the Proceedings of the  National  Academy  of  Sciences,  Professor


Barry  Hall  of Rochester University,  New York,  publishes convincing


evidence for just such an ability.  It  seems  that  some  unexplained


process may be directing mutations in living creatures.





   This  "heresy",  that  creatures  can  change  genes in response to


changing environmental conditions to give  their  offspring  a  better


chance  of  survival,  was propounded in the nineteenth century by the


French biologist Lamarck.  But in this century it was rejected as part


of the modern synthesis called neo-Darwinism.  Last year Hall caused a


stir  when  he came up with support for John Cairns and his colleagues


at the Harvard School of Public Health,  who had  published  tentative


evidence  for  this  process  in  1988.  Hall  took a mutant strain of


bacteria unable to make a nutrient vital for its  survival,  and  then


prevented  them  from  getting  the  nutrient.  He discovered that the


bacteria somehow forced themselves to mutate into a form  which  could


make the nutrient.  This does not square too well with the idea of all


mutations being random.  However,  by depending on just one  mutation,


the  experiment  left  room  to  doubt  that  radical new thinking was


needed.  Now Hall has forced the issue by new experiments in which the


bacteria  have  to  undergo  two mutations.  If the probability of the


bacteria hitting just one mutation correctly is low, the chances of it


getting two right is minute.  And yet he has found  the  same  effect.


Hall calculates that if the results were due to chance,  he would need


about 100 tonnes of bacteria to see just one bacterium change.  In the


event,  he  reports  seeing 37 independent bacteria undergo the double


mutations - exceeding the expectations of  conventional  theory  by  a


factor  of  100 million.  So far,  the results have been restricted to


bacteria,  and it is not clear yet whether the same process is at work


in  more advanced creatures - such as the Bombardier beetle.  However,


Hall does not rule it out, if only because he has no clear explanation


for what is going on in his Petri dishes.  "Finding the  mechanism  is


clearly  the  highest  priority  at  the  moment," he said,  admitting


frankly:  "At this point,  I'm groping around." Finding out  what  the


process  is and controlling it could bring major benefits,  Hall says.


"For  example,   cancer  often  involves   multiple   mutations,   and


understanding  the  process  that  generates  multiple mutations could


provide a major insight into this disease." Whatever its end uses, the


implications of  a  mutation-controlling  force  in  living  creatures


could,  it is argued,  trigger a revolution in biology.  Views of this


sort put Hall rather out on a limb.  An intriguing reaction comes from


Professor John Maynard Smith,  the distinguished theoretical biologist


at Sussex University.  He is not going to tear up his text books  just


yet,  but  last  week  he ventured to say:  "I really do think there's


something interesting going on. One does need to be a bit cautious, of


course.  A cell has to have some way of knowing that  it  must  fix  a


certain mutation - otherwise it is magic!" In the United States,  Hall


is,  however,   bracing  himself  for  a  backlash  from  conservative


biologists:  "The old paradigm that says that mutations are absolutely


random with respect to their usefulness is dead - and that's going  to


be hard for a lot of biologists to swallow."